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Robotic Tray Loader type RTL
STERILINE has jointly developed with one of the worldwide largest pharmaceutical companies a robotic tray loading system. |
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STERILINE GOES ROBOTICS
STERILINE is currently in the process to re-design certain machines in order to simplify their portfolio for aseptic applications. |
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SMALL BATCH FILLING FOR STERILE APPLICATIONS
COMPACT WASHING-,DEPYROGENATING- and FILLING LINE
The STERILINE S.R.L. located in Como, Italy has developed in cooperation with PATHEON a complete small footprint filling line.
The complete line is a modular design which includes washing machine, depyrogenating tunnel and filling machine. The modular design enables the system to be used for ampoule, vial, cardridge or syringe filling.
The COMPACT LINE is suitable for clinical manufacturing, laboratory, R&D applications as well as for small production batches. Based on a monoblock principal, the washing machine is fully integrated with a laminar flow depyrogenation tunnel.The washer/tunnel system can be combined with any STERILINE filling machine to any complete monoblock system.
The integrated rotary washing machine utilizes gripper mechanisms to handle the glassware gently and ensures thorough washing and the siliconization of the glassware. The washing process starts by the glassware being loaded onto a rotating table and then automatically loaded into the grippers. The glassware passes through the washing and drying station in an upside down position. The washer is equipped with needles which are lifted to penetrate the glassware and then spray the appropriate washing fluid(s) and the compressed air or nitrogen for drying.
Conveyor belt. The glassware passes through the inlet chamber then enters the hot chamber, where the depyrogenation process takes place. The glassware never stops moving and then enters the cooling chamber to cool down to a suitable temperature before discharge directly onto the filler in-feed turn-table.
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The conveyor belt system is divided in three parts to increase the efficiency of each chamber.
This system ensures a savings of energy normally lost to the heat up and cool down of the conveyor belt as it passes from chamber to chamber. At the end of the batch, all vials/ampoules are discharged onto the dead plate between the tunnel and the filling machine by means of a discharge bar.
The depyrogenation tunnel has the added advantage of the air being recycled in all the three chambers due to the absence of intake and exhaust ducts. The pressure differential between the cooling chamber and the inlet chamber allows for about 100 air changes per hour in each chamber.
The highly accurate automatic control of air speed in the chambers and of the pressure control inside the depyrogenation tunnel is one of the greatest advantages of this development The depyrogenation tunnel can be equipped with the optional dry heat sterilizable cooling chamber, a heated airtight door is provided. This option also enables the connection of the tunnel to the downstream isolator.
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A user-friendly touch screen HMI provides a seamless interface between the operator and the PLC.
A remarkable breakthrough in technology, in this small footprint, this washing and depyrogenation line is fully compliant with GAMP, cGMP regulations and the latest FDA requirements. The same monoblock concept can also be applied on STERILINES full size production equipment.
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